There are two components to the popular .com.es domain. First, the .com — the most popular domain around. Second, .es, the official domain of the country of Spain. Combining the popularity of one with the locality of the other makes .com.es the perfect domain for people working in or around Spain.
A perfect match.
You don't have to live in Spain to have a .com.es domain, either. That means your business or idea can be anywhere in the world, and if you want to get it in front of a Spanish market, then .com.es is right on. After all, what could go better together than a domain that's well known and a country that's well loved?